You can pay them as independent contractors. They have to sign a W-8 BEN and you can make payments via Wise. If you see that you are hiring a relatively large team from the same country, then at some point you can open a local subsidiary (cost center) and employ them via the local entity. The way to do this has been the same - most US companies became open to this after 2020.
US Sanctions to Venezuela are directed at the government, pdvsa and banks controlled by the government, not at individuals or companies unrelated to them. There's still a lot of business happening between venezuela and the us
People are downvoting but this is correct - I know many being paid in USDT and USDC as well. One benefit is the central bank doesn’t steal your US currency and replace it with the worse (inflationary, poorly accepted) local currency.