Just a few polished examples of that: https://tangramgames.itch.io/tobu-tobu-girl-deluxe
https://user0x7f.itch.io/black-castle
https://binji.itch.io/porklikegb
https://pocketpixel.design/super-jetpak-dx-game-boy-rom.html
https://aiguanachein.itch.io/powa
https://thegreatgallus.itch.io/cavern-mvm-9
https://user0x7f.itch.io/gunship
https://www.infinitygbc.com/
ASM will tend to be more efficient, especially if written by someone with experience and skill, but that isn't enough to prevent other tools from being used successfully. It's described in much more detail in the linked article.