I really appreciated this advice. It's vague enough that if it relates to your life, you'll probably see how when you hear it.
I think I can apply it to both my work life, thinking about times where I overworked myself at a company where nobody else cared enough, and to my personal life, thinking about times where I invested myself fully into relationships where it wasn't certain to be requited.
It feels stressful and lonely because you feel like you have to hold all the strings together and if you fail, the whole project will fail.