For anything networked, not having access to the latest and greatest ciphers, or CA certificates, eventually causes problems. It's possible that mobile formats won't be supported. And a decade or so out, what was once a generous provisioning of storage and memory will frequently come to seem small. Android-based devices such as the Onyx BOOX line probably won't be able to get newer OS updates even if the vendor was willing to support them as Android itself seems to have a moving hardware baseline (I'm typing this on ... an older Android device).
That said, the displays themselves should still function, yes.
Depends on how things are set up with the refresh rate; subpixel rendering may have an effect IIRC. Details I don’t really understand, but e ink has a shorter lifespan than other tech.
The displays will last and function for years. Long enough that other components are generally long obsolete.