[panabee]

thanks for sharing.

does this test for EBV in both latent and lytic phases?

EBV seems very adept at evading the immune system. does this also impact our ability to perform accurate detection (i.e., could current methods yield false negatives)?

[rmind]

EBV VCA IgG antibodies remain present for the rest of your life, as your immune system maintains certain antibody levels to keep the virus in check (it's a delicate host-virus balance).

EBV VCA IgM indicates a primary EBV infection and these antibodies remain for a few months, until seroconversion happens. They might not necessarily be present immediately. During the primary infection, the virus is in active lytic replication which can accurately be shown by an EBV PCR test.

Once the virus establishes latency, EBV PCR will be negative. It may occasionally become positive when EBV reactivates, but it may also reactivate in other compartments i.e. it infects more than just B-cells and the standard PCR test wouldn't show that. There are more antibodies involved and the whole thing is more complex than just the lytic and latent cycles.. the immune system is very complex.

[panabee]

thanks! this answers many questions already. a few more if you don't mind:

1. if VCA IgG antibodies persist for life, how does EBV reactivate?

2. when you say, "may also reactivate in other compartments," this implies that standard PCR tests only verify infection in b-cells? what tests verify infection/activity in epithelial cells?

3. are you on social media? would love to follow you.

[panabee]

4. does VCA IgG detect EBNA2?

[csdvrx]

They have like 2 separate tests: one for old EBV (IGG) and one for new EBV (IGM or maybe it's the other way around?)

IDK about false positive though