Hacker News new | ask | show | jobs
by etaoins 1618 days ago
That’s not correct, furin cleavage sites naturally occur in coronaviruses: https://www.sciencedirect.com/science/article/pii/S187350612...
3 comments
Jimmc414 1618 days ago
You are correct. I should have stated furin cleavage sites have not been observed in another beta coronavirus. (Cold, MERS, SARS) I corrected my statement. Thank you for pointing that out.
link
etaoins 1618 days ago
That’s still incorrect. MERS is a Betacoronavirus and has a furin cleavage site: https://www.pnas.org/content/pnas/111/42/15214.full.pdf

Furin clevage sites haven’t been found elsewhere in SARS-Cov-2’s Sarbecovirus subgenus.

link
moralestapia 1618 days ago
>To clarify this sequence has not been identified in any other virus in the wild.

>this sequence

>this

>sequence

link
finite_jest 1618 days ago
Not with the same PRRAR sequence of amino acids, right?
link
etaoins 1618 days ago
Right, the furin cleavage site seems to have occurred independently in SARS-CoV-2 or one of its undiscovered close relatives.
link