Hacker News new | ask | show | jobs
by tradesurplus 1621 days ago
The intramuscular vaccinations currently available were never going to stop the spread and anyone familiar with animal studies of similar approaches to CoV vaccination knew that. Stating bold claims unsupported by balance of evidence and knowledge of mechanisms was a deliberate choice of messaging in hope of increasing campaign uptake.

They're helpful for preventing severe disease and death, for now -- this effect seems to be significantly offset by reduction in risk avoidance behaviours and government support for said behaviours.

The first gen vaccines do appear help somewhat with reducing infectivity period somewhat.. but once again this benefit is diluted when people are told to burn their source control (masks) and get back to the office.

We need better vaccines deliverable to mucosal membranes for infectious aerosol entry point protection and released under open source licensing. We also need better early treatments with sound scientific basis, and better post-acute-'recovery' sequelae treatments developed with the basis of a growing understanding of endothelial and immune pathology downstream of SARS2 infection.

Second from last but not least, we need efficacious airborne transmission interrupting non-pharmaceutical interventions that don't rely solely on individual behaviour. Finally, it would be nice to have fewer grifters and influencers blocking sound action while spreading nonsense.