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by somenameforme 1624 days ago
The first diagram in the first study you referenced [1] puts the observed rate of myocarditis among patients -without- COVID at 450 per 5 million (9 per 100k). That is much higher than the rate of myocarditis among the entire vaccinated Israeli [2] cohort (125 per 5 million) you mentioned.

The issue is that you're not comparing apples to apples. The Israeli data is looking at the entire population that received the vaccine. The COVID study is only looking at hospitalized patients with/without COVID which is a subset of the entire population restricted entirely to those experiencing the most severe symptoms.

This is not an easy problem to solve. A more apples to apples comparison [3] puts the COVID:vaccine myocarditis ratio at about 6:1, but it also suffers from a bias. In order to measure those rates they relied on the population that tested positive for COVID. This excludes the population of individuals which were infected with COVID but did not received a diagnosis who presumably also had a near 0 rate of myocarditis. This bias [presumably] becomes more pronounced at lower age groups where COVID displays milder symptoms making it less likely to end up diagnosed.

Finally, there is also the consideration that while the vaccines have not yet changed - COVID has. And its likely that the omicron strain will have a different distribution of side effects. It's a difficult problem to solve, and conflicts of interest abound make it all even more challenging.

[1] - https://www.cdc.gov/mmwr/volumes/70/wr/mm7035e5.htm [2] - https://www.nature.com/articles/d41586-021-02740-y [3] - https://www.medrxiv.org/content/10.1101/2021.07.23.21260998v...