Hacker News new | ask | show | jobs
by throwaway2331 1623 days ago
The assortment of medication available for depression is laughable. Even for other neurological disorders, they're so unselective and "broad spectrum," affecting numerous other systems, that it turns into an absurdity: how are we this far behind? Wasn't modern medicine supposed to equal better living?

It's like zero thought has been put into quality of life by practitioners, so long as their metrics are met

E.g. "x, y, z attributes on the ABC scale went down. Looks like you're in remission!"

"But doctor, my dick doesn't work, I've gained 40lbs, and everything feels flat."

"We can prescribe a stimulant for appetite suppression, a vasodilator for the libido... but the 'flat' is all in your head. I'm going to write you a recommendation to a psychologist so they can talk to you about it."

Absolute ninnies.

I understand what you mean about engaging in out-of-personality behaviors, lack of moral code, and the nausea and panic that accompanies the memories of "who you were" on a certain medication (they do go away, with time. And they lose their emotional impact once you accept that it was due to medication, and rationalize it away). They warn you that there might be personality changes, and you'll feel different, but I don't think they understand the absolute gravity of what that means. Even pharmacists go on their soapbox every time you ask for a different brand (because X brand doesn't feel the same, and the FDA has issued numerous warnings about quality control): "the only thing different about brand name medication is the marketing. They're all bio-equivalent and it's all in your head." Fuck off.

This isn't even addressing that it's likely most of the "anti-depressive" effect is placebo in SSRIs and the like. "Oh I feel very different now from this medication. That means it's strong, and effective, and I should be getting better now"; it's in the same vein as chiropractic, except with more woo-woo and theatre ("modern medicine!!!").

There are better substances that can be used off-label/aren't "copyrighted" that actually solve emotional issues by (properly) regulating neurotransmitters and genomic expression to achieve pro-humanist results, instead of soulless pro-metrics and "quantitative" results. But they're not being marketed, because the current batch of psychoactive chemicals is riding on decades of marketing and "works" (see: generates outsized profits).

In my opinion, almost all of these have been a net-negative on society. Opiates, benzos, "anti-psychotics," "anti-depressives," and the like: they're all shit.

There are better chemical (and lifestyle solutions) to these problems, but right now the medical complex has a hard-fought monopoly on health treatment; so anything that would usurp power from them is a no-no (a la "fuck pro-consumer, I'm getting mine").

1 comments

What are these better off label substances?
Hormones:

Most people's androgen:estrogen balance (and levels) are absolutely off kilter, if they live a modern life (no exercise/only exercise is the gym, lack of sunlight, sitting down all day, living in a city, braindead birth control protocols with only estrogens, etc.).

Tuning that would be the most beneficial. And it would get to the root of the problem viz. fixing a mismatched upregulation/downregulate of neurotransmitter receptors (f.e. increasing sensitivity of GABA receptors, decreasing sensitivity of noradrenaline receptors, and so on) -- instead of just a simple and stupid "hur dur lets flood the synaptic cleft with serotonin/dopamine/catecholamines."

Barring that, there exist others that do not disrupt one's natural HPTA, and are more "targeted" towards neurons, rather than the whole body.

Peptides:

There are an assortment of peptides, but their main uses are specifically in gene expression/and cell signal tuning. They're hit or miss. A lot of woo-woo shit going on, and many people hype them up as a cure-all (because there's money to be made); when that's taken into account (and the lack of extensive research), you'll find an assortment of chemicals to play around with.

Russian synthetic adaptogens:

These are their own category of "adaptogens" popular in the Russian medical community (and seeing Western adoption). E.g. semax, bromantane, selank etc. They act as hormones/signaling molecules by changing the expressions of genes (leading to downstream changes of natural peptide levels, behavior of psychological/catecholamine systems, and so on).

-------

All of these, in my opinion and experience, are leagues better than the garbage that is peddled by the U.S's medical community -- because this actually changes shit on the genomic level, rather than fucking with the physical processes outright (ex. imagine the difference between cloud seeding to get more rainfall vs. diverting rivers, to fill aquifers. One of these is much more sustainable and has less side-effects).