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by aos 1626 days ago
Mucinex DM has dextromethorphan[0] which can act as a non-selective serotonin reuptake inhibitor.

[0]: https://en.m.wikipedia.org/wiki/Dextromethorphan see section on dependence and withdrawal

3 comments

It's much stronger effect is as an NMDA antagonist, similar to Ketamine. This blocks one of the primary excitatory neurotransmitters in the brain. That would be a better candidate for a depressant effect than its minor SRI property
Well, that makes sense then. Thanks for the additional info. Honestly have been kinda scared of the whole class of medication that affects mood since this experience, but I've been lucky enough to not feel the need for medication nor been prescribed any of that sort, so haven't had to make that choice.
Serotonin is only a small part of what it does. It can impact everything from NMDA to opioid receptors.

It’s not interchangeable with SSRIs, obviously.