[atoav]

You know how 64x1.2 GHz multicore CPUs can be faster than one single 1.2 GHz CPU?

The same principle works in medicine. Instead of one institute doing 10 trials over 5 years you can also have 10 institutes doing 10 trials in a year (Note: these are not actual numbers, just a show of peinciple).

The trials for the corona vaccines have not been done at a worse quality, as far as I can tell the opposite is actually the case. No vaccine ever had this many critical eyes on it.

[peteradio]

Science does not in general parallelize like that.

[atoav]

I did not claim this is the case in general, but the phases the vaccine trials were conducted more parallel than usually would be the case. See Nature.com:

> The world was able to develop COVID-19 vaccines so quickly because of years of previous research on related viruses and faster ways to manufacture vaccines, enormous funding that allowed firms to run multiple trials in parallel, and regulators moving more quickly than normal.

Source: https://www.nature.com/articles/d41586-020-03626-1

[peteradio]

No amount of parallelism is going to impact the fundamental time constraint of 1 human body. So it goes with pregnancy and so it must go for trusting long term impact. In an ideal world we'd know the second generational impact which would necessarily take 20-40 years. Referring to the awesome parallelism is a red herring to distract from the lack of long term controlled study.

[blub]

While it's very unlikely, we simply don't know if some unknown side-effect will pop up in 10 years and the only way to find out is to wait 10 years and verify empirically.

[atoav]

This is a non-argument. We simply don't know many things before we actually observe them. We don't know whether the stone we let fall a thousand times will still fall after thousand-and-one times. But we can assume it does not, because this wouldn't match the rest of the rules we observed so far.

Granted, RNA vaccines are quite new (although a lot older than the pandemic), but the mechanisms behind RNA are older still. Out cells produce RNA all the time. What you propose is, that RNA produced by our cells today, will somehow miraculously show an effect a decade after it is gone. What is true for the RNA triggered by the vaccine must be true for our own RNA as well. That means our body would have to remember every piece of RNA produced in every cell for a decade.

I am not a medical expert, but I think this is highly unlikely. That would be like drinking a bottle of Schnaps today and being drunk 10 years after it left your body.

[blub]

While you're technically correct, gravity vs. side-effects from vaccines are in wholly different categories.

I don't know enough to judge by myself and agree that it's highly unlikely, but I've noticed that we've been surprised before by these new vaccines: the AZ blood clots came out of the blue and it took about a year for the cause to be discovered - I remember reading that the culprit was accidental injection in the bloodstream after all. Myocarditis is still a mystery.

I call this the "vaccines will turn us into zombies" theory. Quite laughable, but we'll have to wait and see. :-)