I do not use it on the desktop so I have no idea if that works, I would guess that binary graphics drivers are unpatchable with live patch. I've patched the kernel on servers like that for a long time now, I recommended it warmly no problems so far!
It works the same on desktop as servers. I don't run anything that requires binary graphics drivers though (got far, far away from trying to use Nvidia on Linux many years ago), so I can't speak to that.