[JamesBarney]

> The biggest problem is that mice are not humans, and as far as animal models go, they're not even a good one.

A model != an animal. A model is an animal + process for giving the animal a disease.

Mice can be a very good model. As a model for obesity drugs that work through appetite reduction most mouse models are great.

For Alzheimer's all models are terrible (amyloid beta injection, genetic over expression of tau, etc).

"Mice models are bad" sounds profound but doesn't really say anything. Far more informative to say "mouse models of senolytics are bad, and have poor translation to human trials." But we don't know this because we haven't really tried senolytics in humans, so we have no idea if mice are a good or bad model of human senolytics.

I'm idealistic because "mouse gets old and blood vessels don't work as well" is probably pretty similar to "person gets old and blood vessels don't work as well". As opposed to ALS, Alzheimer's, and Parkinson's which mice don't get so we just inject them with stuff we find in the blood and brain of the afflicted.