"The overall protection provided by two doses of ChAdOX1 was considerably lower than that given by BNT162b2. However, infection-acquired immunity boosted with vaccination-induced immunity remained high over a year after infection. Based on these observations, the authors recommend the strategic use of booster vaccines to prevent SARS-CoV-2 infection and transmission in the population."
Is there any indication if double-vax + exposure carries similar benefit?
My wife had 2x Pfizer and then she and our kids got delta. I had 2x Moderna and never had symptoms and tested negative 3 times. No quarantining whatsoever -- slept in the same bed as my wife, the kids still crawled all over me. I still got boosted a few weeks ago, but I've been curious if living in a sick-house with 100% certainty of exposure would carry its own booster effect.
Well I had a pretty bad second dose response. I was bedridden for a week. That said, my COVID infection was far worse and I'm still struggling with long COVID today.
I guess I'm going to have trouble taking a shot (active decision) I know I'll respond badly, albeit temporarily, to. As opposed to waiting around (passive decision) and trying my chances with COVID a second time.
Now that I'm writing this all out, I think I'll get my booster, maybe a fourth if I can weasel my way in.
https://www.news-medical.net/news/20211202/Hybrid-immunity-p...
"The overall protection provided by two doses of ChAdOX1 was considerably lower than that given by BNT162b2. However, infection-acquired immunity boosted with vaccination-induced immunity remained high over a year after infection. Based on these observations, the authors recommend the strategic use of booster vaccines to prevent SARS-CoV-2 infection and transmission in the population."