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by lonesword
1644 days ago
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This won’t work for empirical research. I vividly recall weeks spent trying to reproduce a paper on information retrieval (a deep learning model). What saved me is skimming through the author’s codebase and chancing upon an undocumented sampling step. They were only using the first and last passage in a document as training data and uniformly sampling from 10% of the remaining passages, and the paper didn't mention this. I adopted their sampling strategy, and i was able to obtain their results. My argument is that there are nuances and subtleties that are often omitted in a paper (accidentally or otherwise), but are nevertheless required to reproduce the research. |
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My understanding is the X-ray gives you a diffraction pattern which is hard to invert to a structure, while if you have the structure the diffraction pattern is easy to compute. The diffraction pattern therefore gives you a way to verify that one model is a better fit than another model.
It may not be perfect, certainly not. It might not even be correct once more data arrives. But if you predict a novel fold, and that fold matches the diffraction pattern significantly better than the current model, then it doesn't matter how you came up with the new fold, does it?
It could have been a dream. It could have been search software. The result is still publishable.
All of what you have said is true, but my point is for some research being able to verify the correctness of the result is all that matters, not being able to reproduce the research.
Can you reproduce Kekulé's dream?