[easp]

I found that a major contributor to page generation times on Wordpress is the time taken to load and parse all the PHP files. I installed a PHP opcode cache (APC) as I recall, and it made a huge difference, because the parsed representation of all the Wordpress code is cached in memory (or disk). I'd do that before installing any Wordpress caching plugins, though total cache has other nice features, like minification. Plus it has three different levels of caching. You can cache entire generated pages, and/or objects and/or DB results.