[semerda]

Replication-incompetent adenoviral vectors? Lex Fridman had a virologist on his podcast talking about the mutations done to the adenovirus to make it safe for the delivery of the s-protein (used in viral vector J&J + AstraZ vax). Maybe I misunderstood that?

[somewhereoutth]

Engineered vs evolved.

For sure you can take a virus and knock out the bad bits - but I believe we have no evidence this has occurred in the wild due to selection pressure.

[semerda]

I’m not talking about inactivation with formaldehyde. If they did that in the viral vector it would disable the delivery mechanism (adenovirus).