[hacker934]

> To limit the potential confound of disease states associated with our human brain samples, we compared the biophysical properties of neurons from patients with hippocampal sclerosis; tumour; and other conditions, including gliosis and trauma. We found no significant differences in somatic outside-out currents between the three groups (Extended Data Fig. 7). We also directly tested the effect of epileptic seizures on somatic ionic conductance in rats and found no significant differences (Extended Data Fig. 7). Together, these results suggest that disease aetiology is unlikely to underlie the distinct features of human L5 neurons such as their low conductance.