[LurkingPenguin]

It doesn't look like it.

https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v...

> SARS-CoV-2-naïve vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant (P<0.001) for symptomatic disease as well. When allowing the infection to occur at any time before vaccination (from March 2020 to February 2021), evidence of waning natural immunity was demonstrated, though SARS-CoV-2 naïve vaccinees had a 5.96-fold (95% CI, 4.85 to 7.33) increased risk for breakthrough infection and a 7.13-fold (95% CI, 5.51 to 9.21) increased risk for symptomatic disease. SARS-CoV-2-naïve vaccinees were also at a greater risk for COVID-19-related-hospitalizations compared to those that were previously infected.

[akomtu]

So it's better to get natural immunity while under the effect of vaccine. I'm sure Pfizer would prefer perpetual mandatory boosters because thats a fat revenue stream.

[elzbardico]

Nops, because of antigenic imprinting.

From the wiki (that prefers the annoying name Original Antigenic Sin, probably invented by a theist)

"Original antigenic sin, also known as antigenic imprinting or the Hoskins effect,[1] refers to the propensity of the body's immune system to preferentially utilize immunological memory based on a previous infection when a second slightly different version of that foreign pathogen (e.g. a virus or bacterium) is encountered. This leaves the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections. Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to a form of original antigenic sin, termed repertoire freeze."

https://en.wikipedia.org/wiki/Original_antigenic_sin

[collias]

Correct. It's inconvenient for the current narrative of getting absolutely everyone vaccinated with a spike protein from a single variant, but the best immunity currently available is naturally-obtained.

Also, mostly unrelated, but the word "sin" has little to do with theism, though maybe that's where it's most commonly used. For example, in archery, a miss is called a "sin". I think it's apt for this concept.

[throwntoday]

Better to get natural immunity and just leave it at that. But it you got a vaccine afterwards from what I've gathered your natural antibodies will outcompete whatever the vaccine is producing. The inverse appears to be the same, in that, your body will be unable to produce its own antibodies after getting a vaccine because it is being outcompeted. This seems to pose an issue for variants, as your body will have no way of fighting off a sufficiently mutated virus, it will continue to produce the wrong antibodies. This is known as antibody-dependent enhancement, or ADE, and was a well understood risk prior to rushing out these vaccines.