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Read about senescent cells & chemo. Also, some research shows chemo actually boosts metastasis. Anything targeted beats chemo. Maybe even focused beam radiation (SBRT).

You didn't say which type of cancer.

There is a company called Arvinas that is creating a new class of drugs that tags receptors for destruction by autophagy. Interesting and seemingly more effective than standard of care therapies. However, their targeting seems to be specific to certain mutations on these receptors. Have a look at the investor notes and presentations on their website for more details.