[fnord77]

my AD/immune system anecdote: I have an autoimmune disease. Some ADs make the disease flare up. Some (particularly tricyclics) improve the disease's symptoms.

[ogwh]

Tricyclics (and tetracyclics) tend to be incredibly potent antihistamines, which may explain this.

[fnord77]

I just looked and desipramine has a Ki of 60 for H1, which makes it sort of a weak antihistamine.

Tricyclics are TNF-alpha inhibitors. I believe that's the MOA in my case.