[ttul]

Aren’t many SSRIs antihistaminergic?

[podgaj]

No SSRI's are antihistaminergic. It is right in the name. SSRI only inhibit serotonin reuptake. Many antipsychotics have histamine receptor inhibition, but there are no antidepressants that block the histamine receptors.

[jinder]

Many antidepressants are (e.g. Mirtazapine), but not Sertraline (Zoloft).

[johnisgood]

And some old antihistamines were SSRIs.