Moderna and Pfizer tested variant-specific (B1.351) boosters and found they weren't significantly more-effective than a third dose of the original vaccine.
https://www.nature.com/articles/s41591-021-01527-y
>found they weren't more-effective than a third dose of the original vaccine
This goes against the paper:
>A boost with mRNA-1273.351 appeared to be more
effective at neutralization of the B.1.351 virus than a boost with mRNA-1273, evidenced by the
higher mean GMT levels in the Part C cohort 1 participants (1400) than the GMT Part B
participants (864) against the B.1.351 virus. Additionally, the difference between the wild-type
and B.1.351 assays at day 1 dropped from 7.7-fold prior to the boost with mRNA-1273.351 to
2.6-fold at 15 days after the boost.
Thank you for posting this though -- I was looking for it earlier for my own comment and couldn't find it! Bookmarking now.
This goes against the paper:
>A boost with mRNA-1273.351 appeared to be more effective at neutralization of the B.1.351 virus than a boost with mRNA-1273, evidenced by the higher mean GMT levels in the Part C cohort 1 participants (1400) than the GMT Part B participants (864) against the B.1.351 virus. Additionally, the difference between the wild-type and B.1.351 assays at day 1 dropped from 7.7-fold prior to the boost with mRNA-1273.351 to 2.6-fold at 15 days after the boost.
Thank you for posting this though -- I was looking for it earlier for my own comment and couldn't find it! Bookmarking now.