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Actually humans have cannabinoid receptors. They are components of the hormone transmission in all animals, sans-(insects and Protozoa). Ironically, aspirin interacts with the human cannabinoid system to produce most of its medical benefits. > “ Non-steroidal anti-inflammatory drugs are COX-2 inhibitors that work, in part, by reducing the enzymatic degradation of the endocannabinoid anandamide ” The human endocannabinoid system has vast and far-reaching implications regarding pain, inflammatory system and metobolic regulation. > “ Studies at the National Institute on Drug Abuse in Bethesda, Maryland cloned the G-coupled protein receptor (GPCR) in 1990, which is the target for endogenous cannabinoid ligands, and named it, “Cannabinoid Receptor 1 (CB1 or CBR1). This receptor belongs to the Class A rhodopsin-like family of GPCRs [3]. A few years later, the second GPCR: “Cannabinoid Receptor 2” (CB2 or CBR2) was cloned [4]. The CB1 and the CB2 receptors participate in numerous essential biological processes [5]. Some of these are: Neuronal plasticity [6], pain [7], anxiety [8], inflammation [9], neuro-inflammation [10], immune function [11], metabolic regulation [12], and bone growth [13].” Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770351/ |