Zoning means central planners literally draw a map saying what goes where, and generally make all kinds of aesthetic decisions to go along with it. There is a big gap between that level of micromanaging land use and regulating against nuisances.
No, since this alternative allows for an apartment building with a couple of shops on the ground floor (normal in most of the world), and any other reasonable mixed development.
No one is suggesting heavy industry should be allowed in a residential area.