[tweedledee]

This is absolutely world changing. I've known that this was coming and was only a matter of time, it did get here sooner than I expected. I have hypermobile Ehelers Danlos Syndrome (hEDS) from a TNXB mutation. I was incorrectly told by doctors for decades that I was perfectly healthy and my issues were psychosomatic. It wasn't until I did a careful large scale behavioral analysis that I was able to identify similar people and from there the root cause. A $500 (30x) DNA test confirmed it. hEDS is massively under diagnosed, the vast majority never get a diagnosis.

I strongly suspect that most mental problems are physical in nature and most physical problems are DNA related. And even when they're not DNA related, treatment ideas could be gleaned from 'natures large scale experiment'. The number of issues that can be identified from a $100 (1x) test and then subsequently treated is mind boggling. For me, that cost is less than a single doctors visit. This side steps the medical establishment which is slow and in many ways archaic. This will lead to a massive leap forward in medicine.

In other news; I'm also of the opinion that IQ is largely determined by DNA, nature as opposed to nurture, and once that is properly figured out I'm sure designer babies are next. I don't think that is a door that can be kept closed. There is already a black market for it. I'll be watching from the sidelines, I think this is going to get interesting.

[Kim_Bruning]

I figure DNA works a bit like makefiles. A particular target is only built if it is required somewhere. (And requirements can chain and branch, of course).

So most people realize that height is correlated to diet [given: a functioning gene set; your height is then determined by diet] , strength correlated to exercise [given a fairly broad spectrum that your genes support, exercise will update your strength) , visual accommodation ability to how much you need to accomodate.

But people somehow assume that something as complex and intertwined as an IQ score magically appears, stays constant throughout life, cannot be practiced, and isn't linked to some sort of exercise.

[tweedledee]

You’re talking about phenotypes. With height people with entirely the same diets will end up different heights based on their genes. I used to think that intelligence was earned due to exercise and that others just needed to try harder. I’ve since seen enough people try really hard and fail that I no longer believe that. As with strength, some mutations give some people a big advantage. I don’t think it’s an assumption, there is a lot of evidence. Even the low studies have IQ at 50% DNA and that’s without the greater understandings we have today, I would put it at 80%. Plus likelihood of IQ supporting genes would be much much higher at the extremes.

[Kim_Bruning]

On the one hand, it is certainly very suggestive when you see that children's phenotypes very closely match those of their parents (though you do have to keep an eye out for confounders such as culture or environment even then).

On the other hand, if you try to actually predict things like height or IQ directly from some random genetic sequence someone puts in front of you ... well ... that turns out to be rather tricky.

Have you read any papers that give it a try?

[tudorw]

I think most anyone should have a CYP2D6 test if they are considering taking, or taking, medication, it affects so many drugs out there, yet here in the UK, the GP's I have encountered are not familiar with gene<>drug interactions and I had to request it after working it out myself. It's a complex area, but if you happen to be a poor or ultra metaboliser it's a good thing to know. https://www.ncbi.nlm.nih.gov/books/NBK99699/

[tweedledee]

100% it’s cheap enough that everyone should do it. The TNXB mutation has a ton of weird drug interactions. Anesthesia resistant being just one.

[tudorw]

Have you got a reference for that, I did search but could do with some help!