I doubt GuixSD would work on most modern hardware considering it uses the Linux-libre kernel. Using the Guix package manager itself sounds useful though.
Guix System works fine on modern hardware. I've been using it on new servers for the build farm at ci.guix.gnu.org and on laptops. Linux-libre has not been a problem.
The biggest recurring issue is with graphic cards that have poor support in Linux and require firmware blobs and with WiFi cards that have no free drivers / firmware.
It is trivial to use vanilla Linux with these machines as Guix System lets you use any other package for the `kernel` field in the configuration. The "nonguix" channel (hosted on Github) provides packages for vanilla Linux ("linux") in various versions, and also includes firmware packages that you can use in your config file.
If that's the only thing keeping you from using Guix System then I'm happy to say that it's a hurdle that is very easy to overcome.
> The biggest recurring issue is with graphic cards that have poor support in Linux and require firmware blobs and with WiFi cards that have no free drivers / firmware.
Intel, AMD, and Nvidia GPUS - all of them need firmware blobs to work as expected. Intel and AMD offer free drivers but not free firmware.
And if you want to WiFi 5 (ac) or WiFi 6 (ax), chances are that you'll need non-free drivers/firmware as well.
> The "nonguix" channel (hosted on Github) provides packages for vanilla Linux ("linux") in various versions, and also includes firmware packages that you can use in your config file.
Ah, that's good to know.
I'll probably give the Guix package manager a shot some day.
The biggest recurring issue is with graphic cards that have poor support in Linux and require firmware blobs and with WiFi cards that have no free drivers / firmware.
It is trivial to use vanilla Linux with these machines as Guix System lets you use any other package for the `kernel` field in the configuration. The "nonguix" channel (hosted on Github) provides packages for vanilla Linux ("linux") in various versions, and also includes firmware packages that you can use in your config file.
If that's the only thing keeping you from using Guix System then I'm happy to say that it's a hurdle that is very easy to overcome.