I'm on Safari, with the occasional testing and account segregations with Chrome. The combination of AdGuard[1] (found via SetApp[2]) and NextDNS[3] works for me well on Safari.
I use the AdGuard extension too, with a Raspberry Pi running AdGuard Home which in turn uses NextDNS. I highly recommend every part of this setup, it's maintenance free, extremely reliable and I can't remember the last time an ad or tracker got through it.