[DominikPeters]

Here is a list of alternative UIs for HN: https://blog.luke.lol/tech/hacker-news-alternatives/

Two that display comments: https://hackerweb.app/ https://hn.premii.com/ I don't know how good they are with screenreaders.

[bellweather49]

Brilliant!

The hackerweb.app site seems very good for accessibility. It uses nested lists as others here have suggested.

hn.premii.com is a little more difficult to use (in terms of getting from the list of posts to the comments), but still quite usable. It uses a slightly more complicated layout of divs and lists.