[catdog]

Agree it seems likely that dosing plays a fundamental role.

Moderna while still seeming to suffer from this problem seems to be suffering less than Biontech, they are very similar in general, biggest difference is Moderna having already a longer minimum waiting period between the shots and a way bigger dose of mRNA per shot. So this may already be a hint.

Also currently it looks like a third shot is giving a really great boost compared to the second one, at least in the short term. Same with using mRNA as a booster shot after a vector based vaccine.