The Lavender Hour - comedians Natasha Leggero and Duncan Trussel. The ep A Tea with Reggie Watts and Hairy Gold are mind trips. http://lavenderhour.com/ (horrendous webpage) http://itunes.apple.com/us/podcast/the-lavender-hour/id35058...
Mohr Stories (these give some great insight into Hollywood in general (the first two ep's), and tend to make me laugh out loud throughout. The Bert Kreischer ep is hilarious. http://itunes.apple.com/us/podcast/mohr-stories-smodcast.com...
I also like Adam Carolla, but pick and choose based on the guest. Its hit or miss. The recent Teller ep was great. http://www.adamcarolla.com/ACPBlog/2011/07/29/penn-jillette/