[twoslide]

There is a bit of a statistical artifact here: the number of person-days of people with both doses in the UK is very small during this period. Most adults had no doses or one dose for most of this period.

Vaccination is still great and I encourage everyone who can to get vaccinated, but the 640 people is drawing upon a much smaller population and time period.

[rkk3]

You are mis interpreting the data, there were 640 Covid deaths among those who received both doses, not 640 participants. There were also 68,733 Non Covid deaths among that cohort. Not to mention everyone who didn't die.

[twoslide]

I'm definitely not saying there are 640 participants, just that the size is unknown. Non-Covid deaths is a poor proxy of the population size, as that population is older because of how the vaccination programme worked. I don't think I'm making an interpretation, just pointing out the unknown

[Matthias247]

When I look at the first table I see a number of 220k non Covid death overall compared to 60k after the 2nd dose. Assuming those non Covid cases are constant over time I would assume the sample size is still bigger than 1/4. while not perfect that doesn’t look like „not enough samples“ to me.

[twoslide]

I didn’t say “not enough samples,” only that the population size of fully vaccinated people is not known, and that it changed in the observation period. Therefore, computing mortality rates is not possible, no denominator

[bunje]

I don't understand, there were over 50k non-covid deaths in the twice vaccinated and around 500 covid deaths. That sounds significant, or is it due to the age distribution of twice vaccinated?

[twoslide]

I think the age of the vaccinated population is a confounding factor, I am sure vaccination has a big impact on mortality, just hard to say how much.