[nradov]

Breathing oxygen at a partial pressure over about 0.5 atm causes progressive pulmonary oxygen toxicity (loss of vital capacity). Brief exposures like the treatment protocol described in this paper are fine but it's not something you want to do all day every day. Saturation divers who live under pressure for days are careful to control chamber oxygen pressure below that limit.

Nitrogen is regular air is an anaesthetic. It literally makes you stupid, and the effects increase with pressure. If you want to be smarter you need to replace the nitrogen with helium. The high pitched voices are going to make Zoom meetings hilarious.

So generally working under pressure is totally impractical.