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by eurasiantiger 1741 days ago
Ritalin (methylphenidate) has an effect on one type of serotonin receptors. Most physicians are unaware of this, and, indeed, many think that methylphenidate is an amphetamine derivative, which is not the case.

For many people, d-amphetamine or cannabis are better treatments with less side effects.

3 comments

Ritalin displays no significant activity on 5HT receptors, in contrast to dexamphetamine, which does have significant serotogenic effects.

Yes, they are not related, but both are taken for their dopaminergic effects, though they achieve this by different methods (reuptake inhibitor vs agonist).

Generally, in the course of treatment for ADHD, patients will get to try both to see which one they respond to better. They often exhibit strong preference for one over the other (personally, dex does nothing for me, even at recreational doses of 50mg).

Their risk profiles are very similar, and one cannot be said to have "less side effects", unless referring to a specific individual's response.

Yes, I smoked weed for about 10 years after, partially because it was nice to relax for once even if it made me really dumb while high, and partially because "my brain is already ruined by drugs, what does it even matter at this point?"
Do mean to imply that giving a 10-year-old a few hits from a bong as part of their morning and evening routine is advisable?
Its wild that THAT is where the line is wrt giving drugs to children, particularly in the context of giving kids incredibly powerful, schedule-class stimulants
Yes. One difference is that a number of legitimate studies have linked consumption of THC by those in certain developmental stages with functional deficits in later life (as with alcohol, and FES is definitely a thing). Of course, a rigourous scientific experiment would give definitive proof but would be unethical.

Are there similar studies regarding the ADHD meds?

I suspect the kind of poorly-controlled, correlative studies done for THC would also show correlation between ADHD meds in childhood and a variety of functional problems later in life. (The known comorbities of ADHD alone should account for that.)
Definitely not. Smoke is bad for the lungs.