[simonsarris]

Ranitidine (Zantac) was an extremely commonly prescribed and OTC acid reducer in the US since the 1980's, and was withdrawn in April 2020 because it was found to spontaneously break down into the carcinogen N-nitrosodimethylamine. Only discovered after someone bothered to test. It started with recalls as the carcinogen was detected in some brands, and then a total removal of the product. 40 years of carcinogens. Lots of people still have this in their medicine cabinets.

https://www.fda.gov/drugs/drug-safety-and-availability/fda-u...

Alatrofloxacin (Trovan) was approved in 1997 and withdrawn in 2001 (USA) or 2006 (worldwide) because of serious hepatotoxicity leading to liver transplant or death.

[lamontcg]

neither of which are vaccines.

i also probably ingested a million times more ranitidine than there is mRNA in a vaccine, and the ranitidine still hasn't killed me.

[simonsarris]

You did not ask about vaccines. The parent comment you replied to said medicine.

The Rotavirus vaccine RotaShield was approved in 1998 and withdrawn in 1999 due to risk of intussusception (telescoping intestine).

[lamontcg]

Thing is though that the RotaShield case highlights that vaccines either cause side effects with 3 months or they do not:

> The results of the investigations showed that RotaShield® vaccine caused intussusception in some healthy infants younger than 12 months of age who normally would be at low risk for this condition. The risk of intussusception increased 20 to 30 times over the expected risk for children of this age group within 2 weeks following the first dose of RotaShield® vaccine. The risk increased 3 to 7 times over the expected risk for this age group within two weeks after the second dose of RotaShield® vaccine. There was no increase in the risk of intussusception following the third dose of RotaShield® vaccine, or when three weeks had passed following any dose of the vaccine.

It didn't affect them 5 years later, it happened 2 weeks after the vaccine.

This is typical, and why it isn't particularly necessary to do safety studies of vaccines longer than 3-6 months.

You can argue that the safety study failed in that case and wasn't broad enough and the side effect wasn't noticed so that it wasn't approved, but it was found very quickly after approval, and the rate was 1 in 12,000 vaccinated infants. That is difficult statistically to find in studies of only 25,000 individuals.

And we've had a massive "phase 4" trial of mRNA vaccines involving >100M individuals that has gone on for months now. We know they're incredibly safe.

[anoonmoose]

These anecdotes are absolutely useless without mentioning how many drugs were approved in X year and not withdrawn. Really, it's my fault for humoring this line of thought in the first place.