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In my experience, no it's not worth it indoors in a relatively clean environment. I built 3 of these for myself with dust, carbon, & hepa filters, and I used them for over a year.

They are louder, use more energy, are less efficient, uglier & cost more money than several store bought alternatives which often include several carbon & hepa filter replacements which is the main expense in building these fans.

They work well in the garage though, and if you don't plan on changing the filters frequently they are the cheapest build option.