[CarelessExpert]

> Everybody is making educated guesses in the dark,

We are absolutely not.

Are there many things we don't know about the function of the immune system?

Sure.

Are we "in the dark"? This couldn't be more incorrect, and again, borders on deeply misleading misinformation.

Frankly, this smells a lot like the kind of climate change denial we used to hear. i.e., because there was uncertainty, we therefore can trust nothing and know nothing. And that "logic" was just as flawed, then, as it is now.

[angelzen]

Did we know ahead of time if mRNA vaccine immunity is stronger / weaker than post covid-infection natural immunity? For each strain?

Did we know ahead of time when/where Delta will arise? Did we know ahead of time its infectiousness / virulence parameters?

Do we know when / where the next strain will arise? Do we know if it will be more/less infectious than Delta? Do we know if it will be more/less virulent than Delta? How about per age group?

Do we know whether vaccines protect against potential future vaccine resistant strains? Admittedly an oxymoron, but such is the ridiculousness of this conversation.

What we do know is that the virus is likely to mutate to avoid the narrow spectrum mRNA vaccines. We don't know when / where / how.

That's what I call educated guesses in the dark.

PS. Please do us a favor and keep your ad-hominems for yourself. It may feel good in the moment, but it doesn't strengthen your arguments.

[sjg007]

The virus will mutate no matter what regardless of vaccine. It's not the vaccines that are driving mutations. The vaccine basically programs a set of immune system regex stream filters. Maybe some mutants get past it, well then the immune system will generates another response to it as it goes on to infect other cells in the body etc...

Some of the original variants are thought to have arisen out of immuno-compromised pre-vaccinated patients. Maybe they got IVIg, monoclonal antibodies, or convalescent plasma.