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And really, even if you know python or R, are you really going to fire up a jupyter notebook, load the data, and run pandas queries every time someone in lab meeting or after a talk asks you about this gene or that gene in your data?

I don't do any scientific research, but I have been using jupyter as a replacement for excel since it was called the ipython notebook. I don't really use pandas all that often, I just find it easier to read and edit data in python. Though I first learned ipython added the notebook from a talk Wes McKinney gave about Pandas.