What does intermediate custodian mean here? Something like sendgrid? Is there an issue for normal peoples email on custom domains (eg fastmail or gmail hosted)?
I think he is talking about mailing list servers. When you email mailman, it'll add a line to the bottom of the email, manipulate some to: and cc: headers, and forward it along. This changes the hash of the email which breaks some crypto signatures.
Many European countries are forcing DMARC adoption for government infrastructure and it works just fine.