Hacker News new | ask | show | jobs
by 00deadbeef 1769 days ago
Too much sugar causes high insulin. Prolonged high insulin causes insulin resistance. Insulin resistance causes diabetes.
1 comments

This is a common misconception. Insulin resistance and type 2 diabetes is mostly caused by obesity.

Sugar has a relatively high caloric density and can be addictive, leading to obesity. However, you can eat large amounts of sugar if you do a lot of sport, for example, and then burn off the calories again. Then you don't get diabetes from it either.

> mdbug: Sugar does not cause diabetes.

> mdbug: Insulin resistance and type 2 diabetes is mostly caused by obesity.

Your statements are misleading. Sugar can be addictive. Sugar can also cause obesity. Sugar can also cause insulin resistance. Sugar can also cause diabetes. These concepts are not mutually exclusive.

2007: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235907/

The reviewed evidence supports the theory that, in some circumstances, intermittent access to sugar can lead to behavior and neurochemical changes that resemble the effects of a substance of abuse.

2010: https://pubmed.ncbi.nlm.nih.gov/20138901/

It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories. They may also increase risk of T2DM and CVD as a contributor to a high dietary glycemic load leading to inflammation, insulin resistance and impaired beta-cell function.

2012: https://pubmed.ncbi.nlm.nih.gov/22289979/

Temporal patterns over the past three to four decades have shown a close parallel between the rise in added sugar intake and the global obesity and type 2 diabetes (T2D) epidemics.

2013: https://pubmed.ncbi.nlm.nih.gov/23657152/

The incidence of T2D increased dramatically over the last decades mainly due to Western lifestyle factors such as lack of exercise and high calorie diets. In fact, high-sugar diets are thought to promote weight gain and insulin resistance predisposing to T2D

2015: https://pubmed.ncbi.nlm.nih.gov/26376619/

There are plausible mechanisms and research evidence that supports the suggestion that consumption of excess sugar promotes the development of cardiovascular disease (CVD) and type 2 diabetes (T2DM) both directly and indirectly.

I'll just stop looking there.

> Sugar has a relatively high caloric density and can be addictive, leading to obesity.

Blood sugar triggers the release of insulin to clear it from the blood. Insulin is a hormone that puts the body into an anabolic state so all cells and in particular fat cells begin to store the sugar from the blood. There is a correlation between obesity and T2D, but not causation.

This is why not all T2D patients are obese, rather in every case of T2D you will find someone that regularly consumed sugar/carbs.

That's not true either. You can definitely develop type 2 diabetes without eating carbohydrates.
Can you link to any medical case where the patient did not consume any carbs/sugars and still became insulin resistant?

If a patient consumes no carbs, there would be no high levels of blood sugar, no need for insulin to clear excess sugar from the blood…so I’d really like to see what the medical treatment would be for such a patient.