| The best combo so far (June) was AstraZeneca first then Pfizer (not the opposite, nothing then about Moderna), the next good one will be probably intranasal AstraZeneca after some mRNA: Mixed Oxford/Pfizer vaccine schedules generate robust immune response against COVID-19, finds Oxford-led study:
https://www.ox.ac.uk/news/2021-06-28-mixed-oxfordpfizer-vacc... , ..
https://science.sciencemag.org/content/373/6553/397 - "the ideal
vaccination strategy may use an intramuscular vaccine to elicit a
long-lived systemic IgG response and a broad repertoire of central
memory B and T cells, followed by an intranasal booster that recruits
memory B and T cells to the nasal passages and further guides their
differentiation toward mucosal protection, including IgA secretion and
tissue-resident memory cells in the respiratory tract."
.. (https://news.ycombinator.com/item?id=28019151), https://news.ycombinator.com/item?id=28016821 -
Covid-19 Vaccine Intranasal Study (COV008), UK phase 1 trial recruiting, That said, current vaccines don't provoke the exact same response as an actual infection, particularly in that they don't fully stimulate an immune response in the mucous membranes of the upper repository tract. Here's an Scientific American round-up article (from back in March): https://www.scientificamerican.com/article/to-beat-covid-we-... [..] The current vaccines are excellent at helping the body stop the virus as it progresses into the lungs and further (thus the massive reduction in severe illness and deaths). But it still means that there's a period of a few days after initial infection when a vaccinated person has a relatively naive immune response (while the virus is mostly just in the nose/throat). This would then result in the person still being pretty contagious. (https://news.ycombinator.com/item?id=28014448). I would like to see intranasal Novavax (intranasal mRNA is more difficult ?), having good results, as an option to this mix.. |