Thanks for the citation. Here is a link to the paper cited in the article you've referenced [1]. It does not make claims that are in disagreement with my previous citations.
Quotes from [1]:
- "The notable evolution of neutralizing breadth after infection with SARS-CoV-2 and the robust enhancement of serologic responses and B cell memory achieved with mRNA vaccination SUGGESTS that convalescent individuals who are vaccinated should enjoy high levels of protection against emerging variants without a need to modify existing vaccines."
- "No statistical methods were used to predetermine sample size. The experiments were not randomized and the investigators were not blinded to allocation during experiments and outcome assessment."
In summary [1] shows that "Vaccination increases all components of the humoral response" [1]. This is well established in the literature, and not really up for debate.
However, the mistake you're making is jumping to the conclusion that higher neutralizing titre levels (or antibodies, anti-RBD IgG, etc) are inherently more beneficial. This has not been demonstrated in the literature yet, and it's extremely difficult to determine at what level someone is "protected enough".
Here's a direct quote from the article you linked to, supporting this fact:
- "At the moment, the quantity and vigour of a person’s neutralizing antibodies are the best markers for assessing whether that person is protected from infection and illness — although scientists are still working to confirm that antibody levels can serve as a realistic stand-in for immune protection."
> Your first two citations merely suggest
The evidence provided by [2] goes well beyond "mere suggestion", with statistically significant findings and N = 52,238.
Quote from [2]:
- "The cumulative incidence of SARS-CoV-2 infection remained almost zero among previously infected unvaccinated subjects, previously infected subjects who were vaccinated, and previously uninfected subjects who were vaccinated"
Quotes from [1]:
- "The notable evolution of neutralizing breadth after infection with SARS-CoV-2 and the robust enhancement of serologic responses and B cell memory achieved with mRNA vaccination SUGGESTS that convalescent individuals who are vaccinated should enjoy high levels of protection against emerging variants without a need to modify existing vaccines."
- "No statistical methods were used to predetermine sample size. The experiments were not randomized and the investigators were not blinded to allocation during experiments and outcome assessment."
In summary [1] shows that "Vaccination increases all components of the humoral response" [1]. This is well established in the literature, and not really up for debate.
However, the mistake you're making is jumping to the conclusion that higher neutralizing titre levels (or antibodies, anti-RBD IgG, etc) are inherently more beneficial. This has not been demonstrated in the literature yet, and it's extremely difficult to determine at what level someone is "protected enough".
Here's a direct quote from the article you linked to, supporting this fact:
- "At the moment, the quantity and vigour of a person’s neutralizing antibodies are the best markers for assessing whether that person is protected from infection and illness — although scientists are still working to confirm that antibody levels can serve as a realistic stand-in for immune protection."
> Your first two citations merely suggest
The evidence provided by [2] goes well beyond "mere suggestion", with statistically significant findings and N = 52,238.
Quote from [2]:
- "The cumulative incidence of SARS-CoV-2 infection remained almost zero among previously infected unvaccinated subjects, previously infected subjects who were vaccinated, and previously uninfected subjects who were vaccinated"
[1] Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection https://www.nature.com/articles/s41586-021-03696-9
[2] Necessity of COVID-19 vaccination in previously infected individuals https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v...