[forcry]

Thanks for the answer, but sadly it is not very convincing

>mRNA tech was for a long time believed to be non-essential

Please correct me if I am wrong, but this is is hard to believe. The mRNA tech provide obvious advantages in terms of production and quality control of the vaccines and reduced overall cost, because you no longer have to maintain this library of attenuated viruses..

Also you say

>advantages of mRNA would allow for either a faster development track or for a vaccine that could be changed more rapidly if the virus targeted would mutate.

So you agree that there is obvious advantages to mRNA tech, and we knew it is valuable because the mutation of viruses was not a new discovery that COVID provided.

Also, it seems unlikely that a Company like Moderna would invest in a tech that is currently considered as non-essential.

>The pandemic provided the right circumstances (read: funding)

Yes, this is the crux of my questions. What exactly did the funding enabled? What breakthrough did it yielded?

We already knew that advantages of mRNA would allow for either a faster development track or for a vaccine that could be changed more rapidly. So research funding did not disclose it, we already knew it.

So the questions still stands, sadly.

Also, I came across this article, which kind of says that

>In fact, right before winning federal funding for COVID vaccine development in March 2020, only 3 of Moderna's projects had made it past Phase 1 testing, and only one of these was a vaccine (a cytomegalovirus vaccine codenamed mRNA-1647).

And that kind of refute the claim that it was being blocked because it was seen as non-essential. Or do you think that results of clinical trials are rejected on the basis of how essential the technology is?

https://anthonycolpo.com/the-disturbing-truth-about-moderna-...

[jacquesm]

It is not very convincing because likely nothing would convince you, the answer as given is pretty solid and if you are not convinced then maybe you have yet another answer to why people don't bother engaging with you if you keep spamming the same question over and over again.

[forcry]

Look, if the following is true

>only 3 of Moderna's projects had made it past Phase 1 testing, and only one of these was a vaccine

Is it too much if one wonder how these vaccines got past of the trials that were blocking it, by additional funding. Your answer does not make sense because clinical trials are not evaluated based on whether the technology is essential or not.

I don't think I am being unfair when I say your answer is not very convincing. On the other hand it is not really fair that I ll have to accept what ever that is supposed to be an answer. It might work in television debates, but not in an online forum.

[forcry]

Ok found something

https://anthonycolpo.com/the-junk-science-behind-the-moderna...

It says, among other things..

>Using reasoning that could only make sense to a government bureaucrat or drug company-sponsored researcher, it was decided no Phase 2 trials were necessary for a drug that had just been shown to cause local and systemic side effects in the vast majority of healthy subjects who took it.

[jacquesm]

This guy and his writing have been debunked pretty solidly, you are bringing a wet paper bag to put your bowling ball in.

Just read the bit you quote and try to wrap your head around it: according to him the vast majority of the recipients of the mRNA vaccine had local and systemic side effects, except of course that that never happened...

I'll say this again: there is no evidence that will convince you, but every bit of evidence that confirms your preferred position, no matter how far fetched is taken as gospel.

[forcry]

> This guy and his writing have been debunked pretty solidly,

Can you show me conclusive evidence that phase 2 trials for these vaccines have NOT been skipped?

I have looked and couldn't find it.

[jacquesm]

You seem to misunderstand what a phase 2 trial is for. When you are going 'live' with an emergency authorization because there is a bloody epidemic going on the monitoring of the vaccinations takes the place of the phase 2 trial, hence the various stops whenever something new was discovered. So there hasn't been a phase 2 trial, there won't be a phase 2 trial and you can stop asking about it because it doesn't matter that there wasn't a phase 2 trial.

Look at it this way: whatever size a phase 2 trial would have been it would have delayed the deployment and that would have cost 100's of thousands, quite possibly millions more dead and many tens of millions if not hundreds of millions more people infected. The chance that something major would not surface in the vaccinated population so far that would have surfaced in a phase 2 trial is nil, because the number of people that have now been vaccinated is orders of magnitude larger than the largest ever phase 2 trial.

You do a phase 2 trial when:

(1) you have serious concerns about possible side effects

(2) you have serious concerns about efficiacy

(3) there is no pandemic going on

(4) you want to market your product

The people that made the call to skip the phase 2 trial were experts in their field and apparently decided that (1) was a possibility so they decided to monitor the first couple of million vaccinations closely to see if there would be side effects and whenever those occurred they halted vaccinations until they found out what was up and whether or not there was a way to proceed or to call the whole thing off. AZ in particular ended up being banned for several applications due to an abundance of caution leading to the destruction of a large number of otherwise viable vaccines (and some got donated to countries with less stringent criteria).

(2) never was in doubt, though the exact numbers would only come out after a while and some of the longer term effects in terms of protection and protection against mutations we are only finding out now because some time had to pass for those effects to become apparent.

(3) is obvious, there was a pandemic going on and so every day counted because an exponential process only yields to one thing: fast and mostly accurate decision making, slow and perfect decision making gets you killed every time.

(4) was not much of a problem, regulators and governments alike were begging the companies producing the vaccine to get on with it, because they realized that they had botched their strategy so completely that their only hope was to have a vaccine developed and shipped as fast as possible. Under normal circumstances regulators would have been slower to ensure that all the i's were dotted and all the t's were crossed but in this case they were more than willing to take the -small- risk that a phase 2 trial would have uncovered something really bad that would not come out in the first batch of vaccinations to the general public.

Note that before the general roll-out there had already been a substantial number of people that volunteered to receive the various vaccines and they more than anybody else deserve a lot of credit because they allowed the pharmaceutical companies to compile a mostly complete list of side effects and things to watch for.