It had nothing to do with the United States and the geopolical issues it created. In fact, the Americans sent a commission to Syria which deduced that what the French and Brits were doing was very stupid, at which point the Brits and French told the Americans to piss off.
Perhaps you can first explain why you think that is relevant? AFAIK it was an agreement that the US did not participate in, nor was its intent to destabilize.
https://en.wikipedia.org/wiki/King–Crane_Commission