[dekhn]

human genetics/genomics papers assume you understand an enormous amount of details of human genetics, the knowledge of which has been hard-won over a century. I worked in this field for decades, know a ton, and still have to read every sentence in this paper carefully, multiple ttimes, and check various sources to remind myself of technical concepts. There's a reason I switched to working on computing full time- a lot of these state of the art arguments can only be contributed to by people who are, well, state of the art, thick-skinned, and well-funded.