[pete5x5]

Exactly this - the ability to re-orient your view in a game (or in your mind in the case of the "enemy gate") can be a huge advantage. I personally play much better on bottom side in MOBA games and I have never understood why it can't be flipped. Even if the map is not 'symmetrical' the players could adapt to that change, rather than having to adapt to the change in side each game.

[wincy]

League of Legends: Wild Rift on iOS does this. You’re always the team on the “bottom half” of the map.

[pete5x5]

Yes! Although I didn't like the game (mobile is not usually my jam), it further solidifies my theory that it can work in desktop MOBAs.