[lumost]

I used to do some RNA molecular dynamics simulations in college which were both computationally expensive and difficult to replicate. Having the ability to reasonably predict protein structure is an incredible scientific achievement - however I am curious if anyone here who is better informed has takes on the following.

1. How likely is it that alphafold learned to accurately predict protein structure in the narrow domain of proteins that have been experimentally synthesized and whose structure has been measured? in other words will AlphaFold's results generalize to proteins which cannot yet be synthesized in the laboratory.

2. If Alphafold's accuracy holds, what type of commercial applications does this open up?