|
|
|
|
|
|
by cing
1797 days ago
|
|
|
Everything between the BRCT and RING domains of BRCA1 is an intrinsically unstructured region which DeepMind correctly predicts, https://pubmed.ncbi.nlm.nih.gov/15571721/ Another famous one would be R-domain of CFTR, which was not resolved in experimental structure determination, and AlphaFold models correctly show disorder there. Nothing to be done in those cases except perform molecular simulation or other experiments to assess dynamic ensembles, https://alphafold.ebi.ac.uk/entry/P13569 |
|
|