[chessmiater]

It's not that simple.

Lead poisoning for example takes years to manifest itself.

So did other drugs which took years until regulators retracted them because they did more harm then good.

Specifically about mRNA vaccines, we know little about the long term effects of the lipid nano particles used in them and there are reasons to be concerned.

[_Microft]

As far as I remember there were never serious adverse effects that did not appear within a few weeks of administration of a vaccine. The mRNA technology is conceptually even a lot simpler than other ways of vaccination. What are you exactly afraid about?

[chessmiater]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941620/

[_Microft]

You were alluding to long term effects.

With hundreds of millions of people having received mRNA vaccines by now, we most likely have seen all the short term side effects that there are, except the rarest of them. I would not worry too much about these either.

[adrianN]

What are the reasons to be concerned? To me as a layman the mechanism of action seems very straightforward and not at all concerning.

[chessmiater]

https://cen.acs.org/pharmaceuticals/drug-delivery/Without-li...

https://www.news-medical.net/amp/news/20210315/Research-look...

[adrianN]

Thanks! So the main concern seems to be autoimmune disease?

> Overall, the robust inflammatory milieu induced by LNPs, combined with presentation of the vaccine-derived peptides/protein outside of antigen-presenting cells, might cause tissue damage and exacerbate side effects. Since self-antigen presentation in an inflammatory environment has been linked to autoimmune disease development (Charles A Janeway et al., 2001), this merits further investigation, albeit not detected here.

Because short term inflammation is, as far as I know, not a big deal and somewhat desirable for vaccinations? It is my understanding that we intentionally mix in inflammatory substances ("adjuvants") with normal vaccines to kick the immune system into action?