[mallomarmeasle]

Medicinal Chemist (and former cannabis consumer) here.

>I like weed as a productive drug, it's stronger than caffeine for me, but I develop tolerance...

Interestingly, I used to notice that once I became tolerant to one strain, over a couple weeks, switching to another strain could at least partially alleviate it.

This to me is fascinating. Psychoactive effects of cannabinoids are thought to be mediated by the CB1 receptor. Cannabis strains can vary strongly in their perceived effects. Are there subtypes of the CB1 receptor differentially activated by the various cannabinoids present at different levels in the strains? For instance CB1a and CB1b? I do not think this is known.

>If my focus is better on weed, is there something else I can do for focus that isn't drug related?

This sounds like a line from John Stewart in some stoner movie

[irthomasthomas]

"In 1998, Professors Raphael Mechoulam and Shimon Ben-Shabat posited that the endocannabinoid system demonstrated an “entourage effect” in which a variety of “inactive” metabolites and closely related molecules markedly increased the activity of the primary endogenous cannabinoids, anandamide and 2-arachidonoylglycerol"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334252/#:~:tex...